Meet the Cambridge Scientist on Verge of Curing Multiple Sclerosis

Meet the Cambridge scientist on the curing of multiple sclerosis

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system affecting 2.3 million people worldwide. MS is an immune-mediated disease in which the immune system attacks the protective myelin sheath, which covers the nerve fibers, and causes communication problems between your brain and the rest of your body.

Ultimately, the disease can cause deterioration or permanent deterioration of the nerves. There is currently no cure for MS, but Dr. Su Metcalfe and her company LIFNano hope to change that.

Since there is no cure for autoimmune disease, the mechanism of action for people with MS is to suppress the immune system with medication. Since the brain can not be repaired, like other vital organs, and the high price of MS medications comes with a list of side effects, Su is working on a solution.


The possible remedy

After the discovery of a small binary switch that regulates immune cells. Su is now working with a stem cell particle called LIF that can control the cell and ensure that it does not attack healthy body tissue. At the same time, it protects us and triggers an attack if necessary. LIF Stem Cell Particles are a form of regenerative medicine that plays a role in tissue repair while preserving the health of the brain and spinal cord.

Sus’s approach is what she calls a “double strike”. She finds a way to reverse autoimmunity and repair the damage to the brain. ”

After celebrating her discovery, she had a problem and found that LIF could only survive 20 minutes before being destroyed by the body, which meant there was not enough time for therapeutic intervention. This is where nanoparticle technology comes in.

The role of nanoparticles

A combination of LIF and nanoparticles is biocompatible and dissolves slowly like soluble pitting. The nanoparticles become the administration device that manages the LIF over a period of five days.

As Su notes, “the nanoparticle itself is a protective environment and the enzymes that break it down can not access it.You can also decorate the surface of the particles with antibodies so that they become a targeting device that targets parts you get the right dose in the right place at the right time. ”

The particles themselves have been developed at Yale University, but LIFNano has the worldwide license to use them and Su believes we are on the verge of a revolutionary medicine.

How nano medicine helps

She said, “Nanomedicine is a new era and large pharmaceutical products have already entered this space to deliver drugs while avoiding side effects. The quantum leap is to enter the biology and to open the natural ways of the body.

“We do not take any medicine, we only use body systems for tolerance and self-repair, and there are no side effects because we just keep our balance.

Autoimmunity occurs when the balance is slightly disturbed and we simply put it back in place. Once you’ve done that, it becomes self-sustaining and you do not have to take any more treatment because your body regains its balance. ”

LIFNano has already received two major awards, namely the pharmaceutical group Merck and the government agency Innovate UK. Su hopes to invest more in his work to start clinical trials in 2020.

“We have everything we need to make the nanoparticles clinically compliant – we have to push the switch when we have the money.” We test venture capital companies and large pharmaceutical companies because they have a strong interest in this area. We do all our preclinical work at the same time and at the same time bring the most important resources that the company needs to progress alone. ”
Working with immune cells has been a big part of Sus’s career, she’s passionate about it. “The immune cell is the only cell in the body that represents its own entity and therefore works alone.

It’s probably one of the most powerful cells in the body because it can kill you and if you do not have it, you will die because you do not have it. ”

Although MS is currently at the center of their concerns, this work “will lead to other areas of autoimmune diseases”.

I think we are all waiting for the future with Su and his work with LIFNano. She also explains that “psoriasis is high on our list and diabetes is another.

After all, there is all the dementia because the LIF is an important health factor for the brain – if we can introduce it into the brain, we can begin to protect ourselves from dementia. ”

Your research is meaningful and inspiring. Here you can follow the research and progress of LIFNano.