First US baby ever born to a woman who received a womb transplant from a deceased donor in medical breakthrough
First American baby of a woman who received a transplant from the uterus of a deceased donor as part of a medical breakthrough
The first American baby to be delivered by a deceased donor in the womb was released from the Cleveland Clinic.
Uterine transplants have allowed more than a dozen women, some in the United States, to have the uterus donated by a living donor, such as a friend or family member, who can not do not want to have children.
The girl born in June is unique: her mother received a transplant from a deceased donor – a feat that could make this revolutionary operation a way for many more women with uterine infertility.
The mother, in her thirties, is part of a research study conducted at the Ohio Hospital with 10 women aged 20 to 30, born without a womb to make them infertile.
About one in every 500 women of childbearing age is infertile due to uterine complications.
The uterus was transplanted at the end of 2017. By the end of 2018, the mother became pregnant through in vitro fertilization.
“We could not have hoped for a better result, everything went wonderfully well with the delivery, the mother and the baby are doing well,” said Uma Perni, MD, a specialist in maternal fetal medicine at Cleveland Clinic.
“It’s important to remember that this is still research – the field of uterine transplantation is growing rapidly and it’s exciting to see what opportunities women will have in the future.”
This comes three years after the Cleveland Clinic completed the first uterine transplant in the United States and gave the patient Lindsey McFarland the body of a deceased donor.
Inside the OR: This is a photo from the delivery in early June, with a team of doctors from various specialisms
However, it turned out that the donor was suffering from an undiagnosed bacterial infection called Candida albicans, which required doctors to remove the graft before McFarland and her husband could try to receive it.
For McFarland, this meant that their hopes of carrying a child were over. She was no longer eligible for the trial, but her mother will be the surrogate mother of her baby.
At the Cleveland Clinic, they learn from the mistakes of the past.
The clinic performed five uterine transplants and three were successful. Two women are waiting to try a pregnancy with a new uterus.
These transplants were initiated by a Swedish doctor who succeeded for the first time five years ago.
The concept of uterine graft was considered for the first time in the early 20th century when German surgeons tried unsuccessfully to operate on a transgender patient.
Almost 20 years ago, serious attempts were resumed, first without success in Saudi Arabia in 2000, and again in Turkey in 2011 (a successful transplant, but a failed pregnancy). Finally, in 2012, Swedish surgeons grafted the belly of a mother on her daughter, who was born childless, and in 2014, gave birth to the girl.
After the failure of the Cleveland Clinic’s attempt, Baylor was a success, giving birth to the first American baby after a uterine transplant in Texas in 2017.
Last December, Brazilian doctors announced the first birth in the world of a deceased donor body.
Now the Cleveland Clinic has been added.
“It was amazing how normal this delivery was, given the extraordinary event,” said Drs. med. Andreas Tzakis, transplant surgeon at the Cleveland Clinic.
“Through this research, we want to make these extraordinary events normal for women who choose this option. We thank the donor and her family for their generosity has made our patient’s dream come true and the birth of a new baby. ‘